Hydroxyapatite mouthwash 2026: 6 brands, doses, EU limits
You want a mouthwash with hydroxyapatite and need to know which ones exist, what is in them and what the rules say. We checked the brand pages, ingredient lists, EU and US regulations and the in-situ studies on hydroxyapatite rinses. Every finding carries the date we checked it.
Updated September 2026 · Last reviewed: 26 September 2026 · 28 min read
Disclosure: this guide is by Minvelle. We make a remineralizing gum with nano-hydroxyapatite. It is not a mouthwash and not a toothpaste. Every statement about the products below comes from the brand's own page or label, a regulation, or a paper we resolved in PubMed.
Six brands sell a rinse that states hydroxyapatite: Boka (tablets), Davids, Dr. Jen, Bioniq Repair, Apagard and Biorepair. Only Dr. Jen publishes a percentage, 10% in a US rinse. The EU permits nano-hydroxyapatite in mouthwash up to 0.465% under Regulation (EU) 2024/858. The studies measure bacterial adhesion, not cavities, and they are mixed.
Several popular hydroxyapatite toothpaste brands, RiseWell, Twice, Wellnesse and Lumineux among them, sell a mouthwash with a different active. Three small in-situ studies found hydroxyapatite rinses reduced early bacterial adhesion to enamel over 6 to 24 hours; a fourth found no effect over 48 hours compared with water.
A rinse is in your mouth for seconds. Pick one by what it publishes, keep brushing twice a day, and treat the rinse as an extra, not as your cavity protection.
Where we fit, before the details. Minvelle is a chewing gum for between brushings: one piece a day after a meal, chewed for at least 20 minutes, with 5.7 mg of nano-hydroxyapatite per 1.9 g piece printed on the box. It is not a mouthwash and not a toothpaste, and it does not replace either. If you came here for a rinse, the table below is what you need. If you came here because you want hydroxyapatite in contact with your teeth for longer than a swish, Part 6 is the section to read.
6 hydroxyapatite mouthwash brands, label by label
| Brand and product | Hydroxyapatite form | HAp % | Fluoride | Alcohol | Size | Price | Directions |
|---|---|---|---|---|---|---|---|
| Boka Restore Hydroxyapatite Mouthwash Tablets (US) | Hydroxyapatite, nano or micro not stated | not published | No ingredient panel found | Not stated on the product page | Tablets | $19.99 (1-pack); $34.00 to $36.00 (2-pack) | Chew the tablet, swish, spit |
| Davids Hydroxi fresh breath mouthwash (US) | Nano hydroxyapatite | not published | Fluoride-free (brand states) | Alcohol-free (brand states) | 16 oz bottle; 4 oz concentrate refill, up to 96 uses | $15.95 (kit); $13.95 (refill) | Not captured in our check |
| Dr. Jen's Wellness Mouth Rinse, Cool Mint (US) | Nanohydroxyapatite (nHAp) | 10% (brand's Ingredient Facts) | None listed | Alcohol-free (brand states) | 16 oz | $28.00; $56.00 for 2 | Swish 30 to 60 seconds |
| Bioniq Repair Zahn-Milch (Germany) | Hydroxyapatite, not qualified as nano or micro, plus zinc PCA | not published | None listed | No ethanol (brand states); INCI lists benzyl alcohol | 400 ml | €6.99 | Not captured in our check |
| Apagard RIN-SU (Japan, Sangi) | Nano medical hydroxyapatite (nano mHAP) | not published | None listed | Contains alcohol (INCI) | 380 ml | Not published (no direct shop) | About 7 ml, at least 30 seconds |
| Biorepair Collutorio Protezione Gengive (Italy, Coswell) | Biomimetic hydroxyapatite (Microrepair, zinc-carbonate hydroxyapatite) plus zinc PCA | not published | 0% fluoride (brand states) | 0% alcohol (brand states) | not published | Not published (no checkout) | Not captured in our check |
Swipe sideways on mobile. All figures from each brand's own product page, product feed or published INCI, checked 26 September 2026. Davids also sells a 9 oz oil-pulling rinse with nano hydroxyapatite ($19.95); Biorepair also sells a Triple Action rinse (Collutorio Triplice Azione) with the same hydroxyapatite technology.
Part 1Which hydroxyapatite mouthwashes exist? The six, brand by brand
Search for hydroxyapatite mouthwash and you will see a long list of brand names, most of them known for toothpaste. We went through each candidate brand's own site on 26 September 2026 and kept only products whose own page or ingredient list states hydroxyapatite in the rinse. Six brands passed. For each one we list what the brand publishes and, just as useful, what it does not.
Dr. Jen's Wellness Mouth Rinse: the only one with a published percentage
Dr. Jen Oral Care sells a 16 oz Wellness Mouth Rinse in Cool Mint for $28.00, or $56.00 for two bottles. It is the most transparent product in this guide. The product page carries a full Ingredient Facts table, and that table lists nanohydroxyapatite (nHAp) at 10%. The other listed ingredients include xylitol, aloe vera, calendula-family botanicals, anise, spearmint and peppermint oil, and vitamins D3 and K2.
The brand describes the rinse as alcohol-free, and also free of SLS, chlorhexidine and peroxide. The directions say to swish for 30 to 60 seconds. Dr. Jen is a US brand selling to US customers. Part 3 explains how its 10% figure compares with the limit the EU sets for its own market, and why that comparison says nothing about the rinse breaking a rule. If you want to know more about the brand's toothpaste, our Dr. Jen toothpaste review covers it.
Davids Hydroxi fresh breath mouthwash
Davids Health Sciences sells the Hydroxi fresh breath mouthwash as a kit with a 16 oz bottle for $15.95, and as a 4 oz concentrate refill for $13.95 that the brand says makes up to 96 uses. The product copy, quoted from Davids' own product feed:
"powered by nano hydroxyapatite for enamel health... fluoride free, alcohol free, SLS free formula EWG VERIFIED™ for safe daily use" and, on the refill: "Aids in the remineralization of enamel with nano hydroxyapatite fluoride free, SLS free, no sulfates... alcohol free, non burning formula up to 96 uses per bottle" (davids-usa.com, checked 26 September 2026)
What we could not capture is a full ingredient list with INCI names for this specific rinse, or a hydroxyapatite percentage. The brand names natural mint oils as flavour. So the form (nano) is stated, the amount is not. Davids also sells a second product in this category, the Hydroxi oil pulling oral rinse with nano hydroxyapatite: 9 oz for $19.95, based on MCT coconut oil with peppermint and spearmint oils. Oil pulling is a different routine from a rinse-and-spit mouthwash, so we list it separately. Our Davids toothpaste review covers the brand's pastes.
Boka Restore Hydroxyapatite Mouthwash Tablets
Boka's hydroxyapatite rinse is not a liquid. The Restore Hydroxyapatite Mouthwash Tablets come in Citrus Mint and Mint: you chew a tablet, swish and spit. One pack is $19.99; the 2-pack is listed at $34.00 to $36.00. The product feed gives marketing copy but we found no ingredient panel for this SKU, so we cannot tell you the form (nano or micro), the amount, or whether it contains fluoride or alcohol. The page does not say.
Boka sells a second mouthwash that is easy to confuse with this one: the Renew Prebiotic Liquid Mouthwash, $19.99, which the brand describes as "alcohol-free, pH-balanced" and "enhanced with xylitol". It contains no hydroxyapatite. That liquid rinse was the subject of a 2025 review by BBB National Programs: the National Advertising Division and, on appeal, the National Advertising Review Board looked at Boka parent Essor's prebiotic claim for it. NARB found Essor had "no testing on the product as formulated by Essor" for that claim. The decision concerned the prebiotic liquid, not the hydroxyapatite tablets. Our Boka toothpaste review has the full record.
Bioniq Repair Zahn-Milch
Bioniq Repair, a German brand, sells a 400 ml mouthwash called Zahn-Milch (tooth milk) for €6.99 on its German site. It is the only EU product in this guide that publishes a full ingredient list with a price. The INCI names hydroxyapatite (not qualified as nano, micro or zinc-carbonate), plus zinc PCA, lactoferrin, sodium hyaluronate, xylitol and sorbitol. No hydroxyapatite percentage is given.
On alcohol, the brand says the rinse contains no drinking alcohol (ethanol). The INCI list does include benzyl alcohol, which is a separate ingredient. Both statements are accurate at once; if you avoid every ingredient with alcohol in its name, you will want to know that. On availability: the US storefront's own navigation listed three toothpastes and no mouthwash on 26 September 2026. We did not check the UK or Australian catalogues. Our Bioniq toothpaste review covers the Repair pastes and their published study.
Apagard RIN-SU
Sangi Co., Ltd. in Japan, the company that makes Apagard, lists a 380 ml mouthwash called APAGARD RIN-SU. Its published ingredient list names nano medical hydroxyapatite (the brand writes it nano<mHAP>), xylitol and cetylpyridinium chloride (CPC), and it also lists ALCOHOL. So among the six, this is the one that states it contains alcohol. The directions say to use about 7 ml for at least 30 seconds. Sangi publishes no hydroxyapatite percentage and runs no direct shop on the domain we checked, so there is no brand price to report. Our Apagard toothpaste review covers the brand's pastes.
Biorepair Collutorio: two rinses from Coswell
Coswell SpA in Italy sells Biorepair, whose hydroxyapatite is its own technology, Microrepair: zinc-carbonate hydroxyapatite, which the brand calls "idrossiapatite biomimetica" (biomimetic hydroxyapatite). Two mouthwashes were live on its Italian site on 26 September 2026. The Collutorio Protezione Gengive (Gum Protection Mouthwash) combines the hydroxyapatite with zinc PCA, hyaluronic acid, vitamins A and E, and spirulina, calendula and witch-hazel extracts. Its page states "0% ALCOL, FLUORO e CLOREXIDINA": no alcohol, no fluoride, no chlorhexidine. The Collutorio Triplice Azione (Triple Action Mouthwash) uses the same hydroxyapatite and zinc PCA; its page does not restate the alcohol claim.
Neither page gives a bottle size, a price or a full ingredient list, and the site has no checkout. Biorepair has one advantage no other rinse here has: the product family was tested in a published in-situ study (Part 5). A third product, sometimes called Biorepair Plus mouthwash, has an old sitemap entry, but its dedicated page now redirects to the homepage, so we could not confirm it as a live, separate product.
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Which hydroxyapatite brands sell a mouthwash without hydroxyapatite?
This is the part most lists get wrong. A brand known for hydroxyapatite toothpaste often sells a mouthwash too, and it is natural to assume the rinse contains the same mineral. For several brands we checked, it does not. That is not a flaw in the rinse. It is a different product with a different active, and it is worth knowing before you buy it for the hydroxyapatite.
| Brand | Mouthwash checked | Active per the brand | Hydroxyapatite in the rinse? |
|---|---|---|---|
| RiseWell | Balancing Mouthwash, 16 oz, $16.95; Travel Mouthwash | Xylitol; alcohol-free | No |
| Boka | Renew Prebiotic Liquid Mouthwash, $19.99 | Prebiotic, xylitol; alcohol-free | No (the tablets above are the HAp product) |
| Twice | Gum Shield Mouthwash, 20 fl oz, $8.99 | Cetylpyridinium chloride (CPC); alcohol-free | No |
| Wellnesse | Concentrated Mouthwash, $22.00 | Peppermint, spearmint and cinnamon leaf oils | No |
| Lumineux | Clean and Fresh Mouthwash; Teeth Whitening Mouthwash | Not a hydroxyapatite formula | No |
| Tom's of Maine | Four mouthwash SKUs (fluoride and fluoride-free) | Fluoride on two; none of the four names hydroxyapatite | No |
| Hello | Five mouthwash SKUs | Various, incl. fluoride and antigingivitis rinses | No |
| Karex (Dr. Kurt Wolff) | No mouthwash in the range | Toothpastes and a protective gel only | Not applicable |
| Cocofloss | No mouthwash in the catalogue | Floss and whitening-pen brand | Not applicable |
From each brand's own product catalogue or product page, checked 26 September 2026 (Lumineux from our 25 September 2026 fact check of its product lines).
RiseWell describes its Balancing Mouthwash this way: "alcohol free and powered by Xylitol creating a formula that is clean, safe and incredibly effective at balancing the pH in your mouth." Hydroxyapatite appears nowhere in the product copy. The brand's toothpaste does contain it; our RiseWell toothpaste review covers that. Twice, whose toothpastes contain nano-hydroxyapatite, sells a Gum Shield Mouthwash described as "Advanced gum protection mouthwash with CPC to fight plaque and gingivitis", alcohol-free, $8.99 for 20 fl oz. CPC is an antibacterial active, and a rinse built for gums is a reasonable product. It just is not a hydroxyapatite rinse. Our Twice toothpaste review covers the pastes.
Wellnesse's Concentrated Mouthwash names only essential oils as actives. Lumineux sells a hydroxyapatite toothpaste (see our Lumineux toothpaste review), but its mouthwashes are not hydroxyapatite formulas. Tom's of Maine and Hello each sell several mouthwashes, and none names hydroxyapatite in its title or copy.
Two brands come up in searches but have no mouthwash at all. Karex, the German fluoride-free brand from Dr. Kurt Wolff, sells six products: five toothpastes and a protective gel. Cocofloss sells floss and whitening pens and, in its Cocoshine line, toothpaste, but no rinse; our Cocofloss toothpaste review covers Cocoshine. We also looked at Jason, whose mouthwash collection page showed no products on the day we checked, and at Dr. Brite, whose site refused our connection on every attempt, so we list Dr. Brite neither way.
The practical point: if a mouthwash matters to you because of the hydroxyapatite, read the rinse's own page, not the brand's toothpaste page. For the toothpaste side of the category, our ranking of the best hydroxyapatite toothpastes lists the pastes that publish a percentage.
Six brands, one number
Six brands sell a rinse that states hydroxyapatite. Only Dr. Jen publishes how much: 10%. For the other five, the percentage is not published, and no one outside the company can tell you the dose.
The toothpaste brand is not the rinse
RiseWell, Twice, Wellnesse and Lumineux put hydroxyapatite in their toothpaste but not in their mouthwash. Their rinses use xylitol, CPC or essential oils. Check the rinse's own label.
The studies are about adhesion, and mixed
The in-situ studies measured how many bacteria stuck to enamel. Three short studies found fewer; one 48-hour study found no difference from water. None tested cavities with a retail rinse.
How much nano-hydroxyapatite is allowed in mouthwash? The EU limit
In the EU, mouthwash and toothpaste are cosmetics, and nano-sized ingredients need their own entry in the cosmetics rules. For hydroxyapatite, that entry is Regulation (EU) 2024/858, published in the Official Journal on 15 March 2024 and in force since 4 April 2024 (Annex III, entry 372). It permits hydroxyapatite (nano) up to a maximum of 10% in toothpaste and 0.465% in mouthwash, for rod-shaped particles that are not coated. The limits are based on SCCS opinion SCCS/1648/22, finalised in March 2023. In other words, the ingredient is permitted by Regulation (EU) 2024/858 at those levels, after it was assessed as safe by the SCCS for that particle specification.
The SCCS, the Scientific Committee on Consumer Safety, is the European Commission's scientific advisory committee. It gives opinions; it does not make law. In June 2025 it adopted a newer opinion, SCCS/1677/25 (adopted 26 June 2025), which assessed higher levels as safe for a different particle specification: 29.5% in toothpaste and 10% in mouthwash. As of 26 September 2026, no amending regulation has followed, so that opinion is not law. The limits in force are still 10% and 0.465%. Neither opinion covers chewing gum. Our article on whether nano-hydroxyapatite is safe goes through both opinions in detail.
Why the mouthwash limit is so much lower
The gap between 10% for toothpaste and 0.465% for mouthwash is large. What matters for a shopper is the result: in the EU, a mouthwash can legally contain far less nano-hydroxyapatite than a toothpaste. This is also why EU rinses rarely lead with a percentage. None of the three EU or Japanese products in our table (Bioniq Repair, Apagard, Biorepair) publishes one, and Bioniq and Biorepair do not describe their hydroxyapatite as nano at all.
The 10% US rinse, in context
Dr. Jen's Wellness Mouth Rinse publishes 10% nanohydroxyapatite. That is a fact from the brand's own Ingredient Facts table, and the brand deserves credit for printing it. Set against the EU mouthwash limit of 0.465%, 10% is roughly 21 times higher. The same 10% equals the mouthwash level that the 2025 SCCS opinion assessed as safe for its particle specification; Dr. Jen does not publish its particle shape or coating, so we cannot say whether its particles match that specification.
Here is what that comparison does and does not mean. The EU regulation applies to products placed on the EU market. Dr. Jen is a US brand selling in the US, where EU cosmetics law does not apply, and where hydroxyapatite in a cosmetic rinse needs no premarket approval (Part 4). So the comparison describes two published numbers under two legal systems. It is not a finding that the US rinse breaks any law, and it is not a safety finding in either direction. If you live in the EU and buy products online from other markets, the EU figure tells you what a product made for the EU market could contain.
Part 4How the US regulates hydroxyapatite mouthwash: cosmetic, not drug
In the US, the line between a cosmetic and a drug depends on what the product is for. The FDA puts it this way: "Whether a product is a cosmetic or a drug under the law is determined by a product's intended use." A cosmetic is for "cleansing, beautifying, promoting attractiveness, or altering the appearance." The FDA's own example of an ingredient that makes a product a drug is "fluoride in toothpaste."
Fluoride rinses sold to prevent cavities are over-the-counter drugs under the FDA's anticaries monograph, 21 CFR Part 355. It lists three active ingredients for that purpose: sodium fluoride, sodium monofluorophosphate and stannous fluoride, each at set concentrations. For a treatment rinse, for example, "Sodium fluoride 0.02 percent aqueous solution with a pH of approximately 7" or "Sodium fluoride 0.05 percent aqueous solution". Hydroxyapatite does not appear anywhere in the monograph. It is not a recognised anticavity active in the US.
So a US hydroxyapatite mouthwash that makes only cleansing, freshening or cosmetic claims is regulated as a cosmetic, with no premarket FDA approval required. None of the six brands in this guide combines fluoride with hydroxyapatite in its rinse; where they mention fluoride at all, they say fluoride-free. The monograph even addresses the word itself: "The word 'mouthwash' may be substituted for the word 'rinse' in this statement of identity if the product also has a cosmetic use."
What the fluoride rinse directions tell you about contact time
The same monograph sets the directions for a fluoride anticavity treatment rinse, word for word: "Vigorously swish 10 milliliters of rinse between your teeth for 1 minute and then spit out. Do not swallow the rinse. Do not eat or drink for 30 minutes after rinsing." That is the regulatory benchmark for a rinse: 10 ml, one minute. The hydroxyapatite rinses in this guide ask for similar or shorter times: 30 to 60 seconds for Dr. Jen, about 7 ml for at least 30 seconds for Apagard. We come back to what that means in Part 6.
If you are weighing whether to rinse at all, and when, our guides to rinsing after brushing and alcohol vs alcohol-free mouthwash cover the routine questions. If a dentist has prescribed a chlorhexidine rinse, which several of the studies below used as a reference, read when chlorhexidine helps and when to stop first.
Part 5Does hydroxyapatite mouthwash work? What the studies show
We found four primary studies that tested a hydroxyapatite rinse in people's mouths. All four are in-situ studies: volunteers wore a splint holding small enamel samples, rinsed as instructed, and researchers then counted the bacteria or measured the biofilm on those samples. That is a useful design for early biofilm, but it is not a trial on cavities or gum disease. All four come from the same German research tradition, Hannig-affiliated groups in Homburg and Dresden, and all are small.
| Study | Design and size | Rinse tested | Exposure | Result |
|---|---|---|---|---|
| Hannig et al., 2013, Clin Oral Investig, PMID 22782257 | In situ, bovine enamel on splints, n = 6 | Biorepair preparation with zinc-carbonate hydroxyapatite microclusters; chlorhexidine as reference | 1-minute rinse; bacteria counted at 6 h and 12 h | Fewer adherent bacteria at 12 h than no rinse (2.4×10⁶ vs 1.3×10⁷ per cm²); chlorhexidine lower still |
| Kensche et al., 2017, Arch Oral Biol, PMID 28364672 | In situ, bovine enamel, n = 9 | 8 ml of 5% hydroxyapatite microclusters vs 0.2% chlorhexidine vs no rinse | 8 h overnight | Fewer adherent bacteria than control (2.08×10⁵ vs 2.36×10⁶ per cm², p<0.001); no effect on S. mutans viability |
| Nobre et al., 2021, Nanomaterials, PMID 34578769 | In situ, enamel, titanium, ceramic and resin samples, n = 4 | Three 5% hydroxyapatite solutions vs water vs 0.2% chlorhexidine | Two rinses over 24 h | Most hydroxyapatite-treated samples showed reduced biofilm coverage, comparable to chlorhexidine, without changing bacterial viability |
| Schestakow et al., 2022, Arch Oral Biol, PMID 35257940 | In situ, bovine enamel and dentine, n = 6 | Sterile water vs 5% hydroxyapatite vs 0.2% chlorhexidine | 48 h of biofilm formation | No anti-adherent effect: biofilm 2.3 µm with hydroxyapatite vs 2.1 µm with water; chlorhexidine reduced it |
All four records resolved in PubMed on 26 September 2026. Figures as reported in each abstract.
Hannig and colleagues, 2013: the Biorepair study
This is the only study here that tested a named commercial product. The abstract describes "a new preparation in dental prophylaxis containing zinc-carbonate hydroxyapatite microclusters (Biorepair)". Six volunteers wore upper-jaw splints with bovine enamel slabs, rinsed for 1 minute after 1 minute of pellicle formation, and the researchers counted bacteria at 6 and 12 hours, with chlorhexidine as the reference (Hannig et al., 2013, PMID 22782257).
At 12 hours, unrinsed controls carried about 1.3×10⁷ bacteria per square centimetre. After the Biorepair rinse the figure was about 2.4×10⁶. Chlorhexidine brought it to about 1.3×10⁵. Pure hydroxyapatite microclusters and the liquid phase alone also reduced counts. The authors concluded: "The preparation is an effective compound for biofilm management in the oral cavity due to antiadherent and antibacterial effects." Keep the size in mind: six people and a 12-hour window.
Kensche and colleagues, 2017: overnight
Nine volunteers rinsed with 8 ml of a 5% hydroxyapatite microcluster solution, 0.2% chlorhexidine, or nothing, then wore the splints overnight for 8 hours (Kensche et al., 2017, PMID 28364672). Compared with no rinse (about 2.36×10⁶ bacteria per square centimetre), both rinses cut adherent bacteria significantly: chlorhexidine to about 8.73×10⁴, hydroxyapatite to about 2.08×10⁵ (p<0.001). The hydroxyapatite rinse had no demonstrable effect on the viability of Streptococcus mutans. The authors wrote that hydroxyapatite microclusters "reduced initial bacterial adhesion to enamel in situ considerably and could therefore sensibly supplement current approaches in dental prophylaxis."
Nobre and colleagues, 2021: different surfaces
Four volunteers wore splints carrying enamel, titanium, ceramic and resin samples and rinsed twice over 24 hours with one of three 5% hydroxyapatite solutions that differed in particle shape and size, with water, or with 0.2% chlorhexidine (Nobre et al., 2021, PMID 34578769). The result: "most samples treated with any HAP solution revealed reduced biofilm coverage presenting comparable results to CHX treated samples, however without altering the microorganisms' viability." The authors called a pure hydroxyapatite rinse a possible "promising bioinspired adjunct solution for biofilm management" and declared no conflict of interest. Four volunteers is a very small sample.
Schestakow and colleagues, 2022: no effect at 48 hours
This is the study most lists leave out, and it matters. Six volunteers rinsed with sterile water, 5% hydroxyapatite or 0.2% chlorhexidine under two rinsing protocols while a biofilm formed on their samples for 48 hours (Schestakow et al., 2022, PMID 35257940). In the authors' words: "Rinsing with sterile water or HAP resulted in 2.1 or 2.3 µm thick biofilms, respectively, covering more than half of specimen' surfaces. Despite single deposits of nanoparticles in saliva and biofilm, HAP did not inhibit biofilm formation. Chlorhexidine on the other hand significantly reduced biofilm thickness and coverage." Their conclusion: "Mouthrinses containing HAP nanoparticles showed no anti-adherent effects during 48 h of biofilm formation in-situ."
How to read the four together
The honest summary: in short windows of 6 to 24 hours, hydroxyapatite rinses reduced how many bacteria stuck to enamel, in some cases close to chlorhexidine. Over 48 hours, one study found no difference from water. All four are small (4 to 9 people), all are in situ, none is a randomised trial on cavities or gingivitis, and only the 2013 study tested a product you can buy (Biorepair). The other five rinses in our table have no published study on the rinse as sold that we could find.
You will also see a meta-analysis quoted in this category: Limeback and colleagues (2021, PMID 34925515) pooled hydroxyapatite products of all formats for caries prevention and reported that "HAP provided 17% protection against caries" in a meta-analysis of three randomised trials. Two points before you apply that to a rinse. It is not mouthwash-specific; it pools toothpaste, mouthwash and gels. And the paper discloses that Dr. Kurt Wolff GmbH & Co. KG, which makes Karex, "provided financial support for this review in the form of a small grant for computer expenses", and that two of the three authors "are paid senior scientists at Dr. Kurt Wolff". For the toothpaste literature, our summary of hydroxyapatite toothpaste studies is the better starting point.
Part 6Seconds versus minutes: contact time by format
A mouthwash, a toothpaste and a chewing gum can all carry hydroxyapatite. They differ in how long they are in your mouth. The directions for the rinses in this guide say 30 to 60 seconds (Dr. Jen) or at least 30 seconds (Apagard); the US benchmark for a fluoride treatment rinse is 1 minute. Brushing is typically about 2 minutes, plus whatever stays on the teeth. Minvelle's direction is one piece chewed for at least 20 minutes.
That is a difference in contact time, and we want to be careful not to stretch it further. Contact time alone does not tell you what stays behind afterwards. There is an older study that shows why. Petersson and colleagues (1987, PMID 3477027) measured salivary fluoride in 24 seven-year-old children at 5, 30 and 120 minutes after seven fluoride formats, including chewed and sucked tablets, chewing gum, a 0.2% sodium fluoride mouthrinse, two toothpastes and a varnish. After the varnish and the mouthrinse, salivary fluoride was still significantly raised at 120 minutes compared with the other treatments, and there was no statistical difference between the toothpaste, gum and tablet applications at 30 and 120 minutes.
In plain terms: in that study, a brief rinse left more fluoride in saliva two hours later than the gum did. It is a fluoride study, not a hydroxyapatite one, and it was done in children in 1987, so it does not transfer directly to any product in this guide. We include it because it is the fair counterweight to the obvious point. A gum is in your mouth for 20 minutes; a rinse for under a minute. Which leaves more active behind, and for how long, depends on the ingredient and the format, and for hydroxyapatite nobody has published that comparison.
What we can say without stretching: if you want hydroxyapatite in contact with your teeth for longer than a swish, a gum chewed for 20 minutes is a format that does that by design, and Minvelle states the amount per piece. That is a fact about format and dose. It is not a claim that the gum outperforms a rinse or a toothpaste, and there is no clinical trial on the finished Minvelle gum.
Part 7How to choose a hydroxyapatite mouthwash in five steps
You can run this check on any rinse, including ones launched after this guide was written.
- Confirm the rinse itself contains hydroxyapatite. Read the mouthwash's own page or ingredient list, not the brand's toothpaste page. RiseWell, Twice, Wellnesse and Lumineux show why.
- Look for a number. A percentage or an amount per dose is the only way to compare. Of the six rinses here, only Dr. Jen publishes one (10%). "Not published" is an answer too; note it.
- Check the form and where it is sold. Nano, micro, zinc-carbonate or plain hydroxyapatite are all written differently on labels. In the EU, nano-hydroxyapatite in a mouthwash is permitted up to 0.465% under Regulation (EU) 2024/858.
- Check alcohol and fluoride against your needs. Apagard RIN-SU lists alcohol; Bioniq lists benzyl alcohol but no ethanol; Dr. Jen, Davids and Biorepair state alcohol-free. If you want a fluoride rinse for cavities, none of the six contains fluoride.
- Ask what evidence exists for this exact rinse. Only Biorepair's product family has a published in-situ study. For the others, the studies in Part 5 tested lab solutions, not the rinse on the shelf.
If a tooth hurts, a spot looks chalky or brown, or your gums bleed, skip the rinse aisle and book a dentist. A mouthwash is maintenance, not a diagnosis.
Part 8Where a remineralizing gum fits: between brushings
Most of the day's acid exposure happens between brushings, after meals, snacks and drinks. A toothpaste works when you brush. A rinse works for the half-minute you swish. A remineralizing gum is designed for the time after a meal, and that is the only place we would suggest one. It is an addition to your toothpaste, and to your rinse if you use one, not a replacement for either.
Minvelle is a sugar-free chewing gum with xylitol and nano-hydroxyapatite: 5.7 mg per 1.9 g piece, printed on the box. You chew one piece a day after a meal for at least 20 minutes. Chewing increases saliva flow, and saliva is the mouth's own supply of calcium and phosphate; the gum adds a stated amount of hydroxyapatite during that time. The EU mouthwash and toothpaste limits in Part 3 do not cover gum, and we do not claim they do. Our article on whether an enamel repair gum can rebuild tooth enamel covers what a gum can and cannot do in more depth.
What the gum cannot do
- It does not rebuild lost enamel or fill a cavity. That is a job for a dentist.
- It does not replace brushing or your toothpaste. Keep brushing twice a day.
- It contains no peroxide and does not bleach teeth. The gum contains no peroxide and does not bleach teeth. If you are wondering whether hydroxyapatite changes tooth colour at all, we look at the evidence in does hydroxyapatite whiten teeth.
- It does not freshen breath like a rinse or reach the whole mouth like one. It is a different format for a different moment.
- It has not been in a clinical trial. There is no clinical trial on the finished Minvelle gum. What we publish is the dose, the full ingredient list and a batch certificate from lab testing of the finished gum.
Hydroxyapatite mouthwash and Minvelle, side by side
| Fact | Typical HAp mouthwash in this guide | Minvelle |
|---|---|---|
| Nano-HAp per bottle or piece | Not published for five of six rinses; 10% on Dr. Jen's (US) | 5.7 mg per 1.9 g piece, printed on the box |
| Active | Hydroxyapatite in various forms, often with xylitol, zinc PCA or CPC; no fluoride in any of the six | Nano-hydroxyapatite plus xylitol; fluoride-free |
| What is published | Full ingredient list for three of six (Dr. Jen, Bioniq Repair, Apagard); one in-situ study on a Biorepair preparation | Dose, full ingredient list and batch certificate; no clinical trial on the gum |
| Price and directions | €6.99 to $28.00 per bottle where published; swish 30 to 60 seconds | €24.99 for 18 pieces, 1 piece a day between brushings, at least 20 minutes |
Toothpaste is the brushing base, and a rinse from this guide is a reasonable extra if you like rinsing and want one that states its hydroxyapatite; the gum adds a measured dose between brushings and replaces neither.
Minvelle prints the dose on the box: 5.7 mg nano-hydroxyapatite per piece. See the gum.
In fairnessWhat these rinses do well
A guide that keeps saying "not published" can read as critical, so here is the other side, from the same pages. Dr. Jen publishes a full Ingredient Facts table with a percentage, something no other rinse here does and many toothpastes do not either. Bioniq Repair and Apagard publish full ingredient lists, and Bioniq prices a 400 ml bottle at €6.99, the lowest price in this guide. Davids states its hydroxyapatite form (nano) and sells a refill concentrate. Biorepair's product family is the only one with a published in-situ study, and its Gum Protection rinse states no alcohol, fluoride or chlorhexidine. Boka offers the only tablet format in the group.
The brands that sell a rinse without hydroxyapatite are not doing anything wrong either. RiseWell, Twice and Wellnesse describe their actives plainly on their own pages. A CPC rinse for gums or a xylitol rinse is a legitimate product. It is simply a different product from a hydroxyapatite rinse.
The verdictHydroxyapatite mouthwash, in one paragraph
Six brands sell a rinse that states hydroxyapatite: Boka (tablets), Davids, Dr. Jen, Bioniq Repair, Apagard and Biorepair. If a published percentage matters most, Dr. Jen is the only one with a number, 10%, in a US rinse. If you are in the EU and want a full ingredient list at a low price, Bioniq Repair Zahn-Milch lists everything at €6.99 for 400 ml. If you want a rinse from a product family with a published study, that is Biorepair. The EU permits nano-hydroxyapatite in mouthwash up to 0.465% under Regulation (EU) 2024/858, a limit that applies to the EU market. The studies show reduced early bacterial adhesion in short windows and no effect at 48 hours, and none tested cavities. Use a hydroxyapatite rinse as an extra, keep your toothpaste as the base, and do not expect a swish to do the job of either brushing or a dentist.
Facts checked on 26 September 2026 from the sources below. If a brand changes its formula, label or price, tell us and we will update this guide.
Hydroxyapatite (HAp): A calcium phosphate mineral, the main mineral in tooth enamel. In oral care it appears as nano, micro or zinc-carbonate hydroxyapatite, depending on particle size and chemistry.
Nano-hydroxyapatite: Hydroxyapatite with nanometre-scale particles. In the EU it has its own entry in the cosmetics rules: up to 10% in toothpaste and 0.465% in mouthwash, rod-shaped and uncoated.
In-situ study: A study in which volunteers wear small tooth samples in their mouths on a splint, so researchers can measure effects in real saliva without testing on the volunteers' own teeth.
Bacterial adhesion: Bacteria sticking to the tooth surface, the first step of plaque. The hydroxyapatite rinse studies in this guide measured this, not cavities.
Chlorhexidine (CHX): An antiseptic rinse used as the reference in all four studies here. In the 48-hour study it reduced biofilm where hydroxyapatite did not.
SCCS: The Scientific Committee on Consumer Safety, the European Commission's scientific advisory committee. It gives safety opinions; the Commission and the regulation set the limits.
The things people actually ask
Is there a mouthwash with hydroxyapatite?
Yes, but fewer than you might expect. On 26 September 2026 we confirmed six brands selling a rinse that states hydroxyapatite on their own pages: Boka (tablets), Davids, Dr. Jen, Bioniq Repair, Apagard and Biorepair. Several better-known hydroxyapatite toothpaste brands, including RiseWell, Twice, Wellnesse and Lumineux, sell a mouthwash with a different active.
How much nano-hydroxyapatite is allowed in mouthwash in the EU?
Regulation (EU) 2024/858, in force since 4 April 2024, permits hydroxyapatite (nano) up to 0.465% in mouthwash and up to 10% in toothpaste, for rod-shaped, uncoated particles, based on SCCS opinion SCCS/1648/22. A 2025 SCCS opinion (SCCS/1677/25) assessed higher levels as safe for a different particle specification, but that is an opinion, not law, as of 26 September 2026.
Which hydroxyapatite mouthwash publishes its percentage?
Only one of the six: Dr. Jen's Wellness Mouth Rinse lists 10% nanohydroxyapatite in the Ingredient Facts table on its product page. It is a US product sold under US rules. Boka, Davids, Bioniq Repair, Apagard and Biorepair do not publish a hydroxyapatite percentage for their rinses.
Does hydroxyapatite mouthwash work?
The studies we found measure bacterial adhesion to enamel, not cavities. Three small in-situ studies (Hannig 2013, Kensche 2017, Nobre 2021) found hydroxyapatite rinses reduced early bacterial adhesion over 6 to 24 hours. A fourth (Schestakow 2022) found no anti-adherent effect over 48 hours compared with water. None is a caries trial on a retail rinse.
Which hydroxyapatite mouthwash is alcohol-free?
Dr. Jen and Davids state alcohol-free. Biorepair states 0% alcohol on its Gum Protection rinse. Bioniq Repair says it contains no drinking alcohol (ethanol), and its ingredient list includes benzyl alcohol, a different ingredient. Apagard RIN-SU lists alcohol as an ingredient. Boka's tablet page does not state it either way.
Is hydroxyapatite mouthwash better than fluoride mouthwash?
The evidence does not answer that directly. In the US, fluoride rinses are regulated anticavity drugs with set concentrations and directions, and hydroxyapatite is not on that list. The hydroxyapatite rinse studies in this guide measure bacterial adhesion, not cavities. If you rely on a rinse for cavity protection, ask your dentist which one suits you.
Medical disclaimer: this article is educational and is no medical advice. It does not diagnose, treat or replace professional care. Talk to your dentist before changing your oral-care routine, especially before replacing a prescribed or fluoride rinse, and see a dentist about any visible spot, hole, pain, bleeding or sensitivity that lasts. Product formulations, labels and regulations change over time; always check the current label.
- Hannig C, Basche S, Burghardt T, Al-Ahmad A, et al. Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ. Clin Oral Investig 2013. PMID 22782257
- Kensche A, Holder C, Basche S, Tahan N, et al. Efficacy of a mouthrinse based on hydroxyapatite to reduce initial bacterial colonisation in situ. Arch Oral Biol 2017. PMID 28364672
- Nobre CMG, König B, Pütz N, Hannig M. Hydroxyapatite-based solution as adjunct treatment for biofilm management: an in situ study. Nanomaterials 2021. PMID 34578769
- Schestakow A, Pütz N, Guth MS, Eisenmenger TA, et al. Influence of a hydroxyapatite suspension on 48-h dental biofilm formation in-situ. Arch Oral Biol 2022. PMID 35257940
- Limeback H, Enax J, Meyer F. Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis. Can J Dent Hyg 2021. PMID 34925515
- Petersson LG, Ludvigsson N, Ullbro C, Gleerup A, Koch G. Fluoride clearance of whole saliva in young school children after topical application. Swed Dent J 1987. PMID 3477027
- Commission Regulation (EU) 2024/858, amending Regulation (EC) No 1223/2009 as regards nanomaterials (hydroxyapatite (nano), Annex III entry 372)
- 21 CFR Part 355, Anticaries drug products for over-the-counter human use (eCFR)
- FDA: Is it a cosmetic, a drug, or both? (Or is it soap?)
Also checked, without a link: SCCS opinions SCCS/1648/22 (final March 2023) and SCCS/1677/25 (adopted 26 June 2025). Brand pages and product feeds, quoted above and checked 26 September 2026: Boka, Davids, Dr. Jen, Bioniq Repair (German and US sites), Sangi (Apagard RIN-SU), Biorepair (Collutorio Protezione Gengive, Collutorio Triplice Azione, sitemap), RiseWell, Twice, Wellnesse, Tom's of Maine, Hello, Cocofloss, Karex and Jason; Lumineux product lines from our fact check of 25 September 2026. The BBB National Programs NAD and NARB decisions of 2025 on Boka parent Essor.
About the author
Max, Founder of Minvelle, builds an oral-care brand around one rule: publish the numbers, cite the sources, and say plainly what a product cannot do. He is not a dentist and does not play one online, which is why every article on this blog ends by pointing you to yours. The full formula behind Minvelle, every ingredient and dose, is public on the transparency page.
The answer in one line: six brands sell a hydroxyapatite mouthwash, only one publishes its percentage, and the EU permits nano-hydroxyapatite in mouthwash up to 0.465%. The rinse studies show fewer bacteria sticking to enamel in short windows and no effect at 48 hours. Pick a rinse by what it publishes, keep brushing twice a day, and see a dentist for anything that hurts or looks wrong. If you also want a measured dose of nano-hydroxyapatite between brushings, that is a separate, added step. All findings reflect the listed pages and records as checked on 26 September 2026.
Keep your toothpaste. Add a dose in writing.
Brush with the paste that fits your need. Minvelle is for between brushings: 5.7 mg of nano-hydroxyapatite per piece, printed on the box, xylitol-sweetened, one piece a day chewed for at least 20 minutes. 18 pieces per box, batch certificate published.
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